学术成果
 


一、SCI论文:
1.Publications from China in The Lancet, NEJM and JAMA. The Lancet, 2013.
2.HIV-1gp120 reduces the Expression and Functions of Endothelial Nitric Oxide Synthase in TNF-alpha Activated Porcine and Human Endothelial Cells. Cardiovascular Research 2010,87 (2): 366-374.
3.MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. Carcinogenesis ,2012, 33(3):519-528.
4.Construction and In Vitro/In Vivo Targeting of PSMA-Targeted Nanoscale Microbubbles in Prostate Cancer. Prostate ,2013,73(11):1147-58.
5.Polymorphic CABYR expressed in the late steps of spermiogenesis and binds with AKAP3, AKAP4 and ropporin in mouse sperm fibrous sheath . J Urol. 2008,179(4):618.
6.Construction of a DNA vaccine encoding Flk-1 extracellular domain and C3d fusion gene and investigation of its suppressing eVect on tumor growth .cancer immunology immunotherapy,2010,59(1):93-101.
7.Clinical analysis of the characterization of magnetic resonance imaging in 102 cases of refractory hematospermia. Andrology 2013 Nov;1(6):948-56.
8.Preparation of Nanobubbles Carrying Androgen Receptor siRNA and Their Inhibitory Effects on Androgen-Independent Prostate Cancer when Combined with Ultrasonic Irradiation. PLOS ONE,2014,9(5):e96586.
9.Administration of dendirtic cells dual expressing DcR3 and GAD65 mediates the suppereeion of T cells and induces long-term acceptance of pancreatic-islet transplantation. Vaccine,2010,28(2010)8300-8305.
10.Vaccination with a chaperone comple x based on PSCA and GRP170 adjuvant envhances the CTL response ad inhibits the tumor growth in mice. Vaccine,2010,28(2010):6333-6337.
11.Induction of protective and therapeutic antitumor immunity by a DNA vaccine with Csd as molecular adjuvant. Vaccine,2010,28(2010):7221-7227.
12.Immunocontraceptive effect of DNA vaccine targeting Fertilin B in male mice. American Journal of Reproductive Immunology, 2010,282-290.
13.Treatment of runery fistula after kidney transplentaion. Transplant Proceedings,2009,41,1624-1626.
14.Complex behaviours-new targets against cancer. Nature Reviews. Clinical Oncology, 2013,10(2):319-28.
15.Effect or insulin on oogenesis from mouse fetal germ cells in a serum-free 3D culture system. Reproductive biomedicine online,2010,20:11-25.
16.Imaging diagnosis, transurethral endoscopic observation and management for 43 cases of severe and refractory hematospermia. J Androl. 2012,33(5):906-16.
17.Alteration in methylation pattern of oncogene Akt1 promoter region in bladder cancer. Mol Biol Rep,2011,5(39):5631-36.
18.A Novel DNA/Peptide Combined Vaccine Induces PSCA-specific Cytotoxic T-lymphocyte Responses and Suppresses Tumor Growth in Experimental Prostate Cancer. Urology. 2012,79(6): 1411.
19.Caspase-3 is Involved in IFN-γ-and TNF-α-Mediated MIN6 Cells Apoptosis via NF-κB /Bcl-2 Pathway.. Cell Biochem Biophys ,2013,67:1239–1248.
20.CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath. Reproductive Biology and Endocrinology, 2010, 8:101.
21.CABYR binds with AKAP3 and Ropporin in human sperm fibrous sheath. Asia Journal of Andrology. 2011,13:266-274.
22.Transumbilical laparoendoscopic single-site renal pedicle lymphatic disconnection for refractory chyluria. J Endourol. 2011;25(8):1337-1341.
23.Transumbilical Laparoendoscopic Single-Site Renal Pedicle Lymphatic Disconnection for Refractory Chyluria.lournal of endourolgy,2011,25(8):1337-1341.
24.Expression and Clinical Implications of Homeobox Gene Six1 in Cervical Cancer Cell Lines and Cervical Epithelial Tissues. International Journal of Gynecological Cancer,2010,20(9):1587-1592.
25.Pedicled Greater Omentum Graft: A New Technique to Repair Recurrent Urinary Fistulae After Kidney Transplantation. Cell Biochem Biophys, 2012, 62:69-72.
26.Comparison of Urologic Complications with Primary Ureteroureterostomy versus Conventional Uerteroneocystostomy. Clin Transplant,2009,12(18)
27.LC-MS for in vitro determination of a novel epothilone D derivative (Epo D -HD) in human plama . chromatographia.2010,71:923-926.
28.Diagnosis and treatment of hyper-delayed graft function after renal transplantation. Urologia. 2012,88(3):326-32.
29.Penetrating injury of the vagina, bladder and omentum in a woman with 5 months gestation: case report and review of the literature. International urology and nephrology,2014,46(6):1137-1140.
30.Urological Complications in 1223 Kideny Transplants. Urol Int,2009,83:337-341.
31.Diagnosis and treatment of hyper-delayed graft function after renal transplantation. Urol Int. 2012,88(3):326-32.
32.Surgical Management of Intractable Chyluria: A Comparison of Retroperitoneoscopy with Open Surgery. Urol Int 2012;89:222–226.
33.Pedicled greater omentum  graft: A posxble approach for reducing the incidence of wrinary fistula after kidney transplantation . Medical Hypotheses,2009,73:626-627.
34.The roles of LSD1-mediated epigenetic modifications in maintaining the pluripotency of bladder cancer stem cells. Med Hypotheses,2013;81(5):823-5.
35.Acute Femoral Neuropathy Following Renal Transplantation: A Retrospective, Multicenter Study in China. Transplantation Proceedings,2010;42(5):1699-1703.
36.High ligation of internal spermatic vein under single-port  Transumbilical laparoscopy in young patients. Scientific Research and Essays.2011,6(6):. 1281-1284.
37.Role of fluorescence in situ hybridizataion in the diagnosis of urothelial cancer in asymptomatic hematuria patients. Scientific Research and Essays. 2011,6(26).
38.DNA methylation of PTEN gene promoter region is not correlated with urocystic  tumorigenesis. African Journal of Biotechnology 2012,11(16):3868-3873.
39.Management of Complete Ureteral Avulsion and Literature Review: A Report on Four Cases. Journal fo Endourology,2011;25(2):323-326.

二、承担课题
1)国家自然科学基金:基于FLK1-C3d的抗血管生成疫苗的构建及效应研究年;
2)国家自然科学基金:靶向于肾癌的多功能纳米级微泡的制备及其效能评价;
3)国家自然科学基金:二甲双胍抑制STAT3信号增敏bicalutamide对前列腺癌治疗作用研究;
4)国家自然科学基金: C5aR通路促Fgl2表达介导缺血再灌注肾损伤的分子机制;
5)国家自然科学基金:低氧诱导PHF8在前列腺癌雄激素非依赖性发生中的作用机制;
6)国家自然科学基金:补体C3对肾移植排斥反应中Th17细胞的调控作用;
7)国家自然科学基金:精子形成相关基因Fscb敲除小鼠模型建立及其表型研究;
8)国家自然科学基金:基于Bin1b的雄性免疫节育DNA疫苗构建及其效应研究;
9)国家自然科学基金:膀胱肿瘤树突状细胞疫苗的制备及程序性死亡配体对其免疫应答的影响年;
10)国家自然科学基金:纤维鞘蛋白FSCB磷酸化在鼠精子获能和超活化中作用的研究;
11)国家自然科学基金: PSCA-DNA颗粒型复合型疫苗的构建及效应研究;
12)国家农业部重大专项分课题:优质高产转基因羊肉新品系培育;
13)国家卫生部课题:原位荧光杂交在早期膀胱癌诊断中的应用;
14)重庆市国际合作项目:人体组织器官无痕快速焊接仪联合研发;
15)重庆市科委基础: LSD1调控的发育基因表观遗传学修饰在膀胱癌干细胞多能性维持中的作用与机制;
16)重庆市重大科技攻关课题:功能化组织工程尿道的构建及临床应用研究;
17)重庆市自然科学基金:一种抗癌新型融合多肽的初步研制;
18)重庆市科委国际合作课题:组蛋白去甲基化酶PHF8在前列腺癌雄激素非依赖性及进展中的作用;
19)重庆市自然科学基金: rPB-DR(6)调控的溶瘤腺病毒对前列腺癌细胞的杀伤作用研究;
20)重庆市自然科学基金: C3d3介导的Bin1b疫苗构建及免疫节育效应研究;
21)重庆市科委攻关课题:雄激素非依赖型前列腺癌基因治疗的靶向性研究;
22)重庆市自然科学基金:初发与复发高危性膀胱癌差异表达蛋白谱的建立及分析;
23)重庆市自然科学基金:人精子运动超活化相关蛋白的FSCB的克隆表达和功能研究;
24)重庆市自然科学基金:一种新型颗粒型前列腺癌疫苗的构建及效应研究;
25)重庆市自然科学基金:RNA干扰技术沉默雄激素受体基因及其对前列腺癌细胞生长的抑制作用研究;
26)总参教学训练项目:泌尿外科内镜与微创手术培训中心;
27)全军优生优育技术中心课题:人精子FSCB蛋白在运动功能障碍精子中的表达及与男性不育关系的研究;
28)全军优生优育技术中心课题:慢性前列腺炎和男性不育相关性及其机制研究;
29)高原医学教育部重点实验室开发课题:高原条件下缺氧诱导因子-1在大鼠睾丸生殖细胞的表达;
30)第三军医大学校临床科研基金:急性移植肾功能损伤的早期预警诊断;
31)第三军医大学校临床科研基金:基因-放射联合治疗前列腺癌的实验研究;
32)“创伤、烧伤与复合伤国家重点实验室”开放基金:微波辐射环境下睾丸内睾酮浓度,血睾酮浓度对精子的发生的关系研究;
33)第三军医大学校临床科研基金:基因药物前体活化疗法治疗前列腺癌的实验研究;
34)第三军医大学校临床科研基金:睾丸内睾酮浓度与精子发生的关系研究;
35)第三军医大学校临床科研基金:PSCA-DNA颗粒型复合型疫苗的分子构建;
36)第三军医大学校临床科研基金:鼠精子纤维鞘钙结合蛋白的FSCB的动态表达及与精子获解关系的研究;
37)第三军医大学归国人员启动基金:急性移植肾功能损伤的早期预警诊断;
38)第三军医大学校临床科研基金:CLDN3作为候选癌标在前列腺癌诊治中的应用研究。


三、主编出版的专著:
1.主编《前列腺疾病诊疗指南》2008年,人民卫生出版社
2.主编《肾移植并发症防治指南》2009年,人民卫生出版社
3.主编《微创泌尿外科护理手册》2009年,人民军医出版社
4.主编《肾移植手术技巧》2010年,人民卫生出版社
5.主编《失禁管理手册》2011年,人民卫生出版社


四、成果奖励
1.军队医疗成果二等奖:肾移植慢性排斥反应发生机理与防治策略,2008年;
2.军队医疗成果二等奖:肾移植围手术期护理策略,2009年;
3.校新技术新业务奖一等乙级:带蒂大网膜修补肾移植术后复杂性尿瘘;2009年;
4.校新技术新业务奖二级甲等:经阴道联合腹腔镜根治女性全膀胱切除原位回肠新膀胱术;2009年;
5.校新技术新业务奖一级乙等:肾移植术后复杂性尿瘘的诊断与治疗,2009年;
6.重庆市科技进步一等奖:提高肾移植质量的基础与临床研究;2010年;
7.军队医疗成果二等奖:肾移植术后尿瘘分类诊断标准及治疗方案的建立;2010年;
8.校新技术新业务奖护理类一级:超声冲洗联合湿性敷料在慢性难愈合伤口中的应用;2010年;
9.校新技术新业务奖二级甲等:多种路径单孔技术在泌尿领域的应用研究;2010年;
10.校新技术新业务奖一级乙等:经脐单孔腹腔镜下肾蒂淋巴管剥脱术,2011年;
11.军队医疗成果二等奖:泌尿外科腹腔镜手术的技术改进与临床应用;2012年;
12.校新技术新业务二级甲等:无管化经皮肾镜取石术,2013年。


五、专利情况
国家发明专利:
1)器官移植端侧吻合器 ZL2009210104639.3
2)一种治疗男性不育症的药物 ZL200710078144.9
3)前列腺干细胞抗原多肽与核酸的复合物及其制备方法与应用ZL201110228380.0
4)输精管附睾镜系统ZL201110300353.X
5)输精管支架ZL201110300352.5
6)一种避孕节育DNA疫苗及其制备方法ZL201410541822.0
实用新型专利:
1)多功能医用鼻罩 ZL200920126814.4
2)阴茎夹 ZL201020160904.8
3)睾丸穿刺活检器 ZL201020160915.6
4)一种多腔导尿管 ZL200920146112.2
5)一种多腔导管 ZL200920146111.8
6)前尿道支架管 ZL200920126155.4
7)尿道扩张器 ZL200820100821.2
8)会阴部伤口保护支架 ZL200620111417.6
9)带刻度及侧孔的窦道探针 ZL200720125271.5
10)一种多功能新型尿管 ZL200720188318.2
11)腔镜微创手术的缝合器 ZL200920304633.6
12)胸腹腔筋膜缝合器 ZL200920303867.9
13)新型伤口冲洗废液引流器 ZL200920206442.6
14)可移动升降式伤口废液引流装置 ZL200920206456.8
15)医用自动负压引流装置 ZL200920128506.5
16)新型多功能引流管 ZL200920128505
17)阴茎伤保护器 ZL201020134508.8
18)医用快速加热装置 ZL201120182287.6
19)精确定位的气囊导尿管 ZL201120275904.7
20)导尿管注射接头 ZL201120275893.2
21)用于隐睾术后睾丸的牵引装置 ZL201120259502.8
22)用于防止血液反流的输液器 ZL201120275870.1
23)连动式锐器收集盒 ZL201120440767.8
24)一体式输液头皮针 ZL201120440775.2
25)用于前列腺手术后的牵引装置 ZL201120394778.7
26)用于包皮环切术后的网眼纱布 ZL201110394782.3
27)内窥镜光源支架 ZL201120155263.1
28)医用固定带 ZL201120181712.X

 


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